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Tirzepatide (Mounjaro®) vs Semaglutide (Wegovy(TM)): What’s Better for Weight Loss?

June 9, 2023

When it comes to shots for weight loss, many people are torn between the two big names: Tirzepatide (Mounjaro®) and Semaglutide (WegovyTM). While both offer advantages, it can be tough to decide which one will help you best on your journey to a healthier, slimmer you. In this blog, follow along as we explain the differences between these two popular shots so that you can get a better understanding of which could be most beneficial.

The Main Differences Between Tirzepatide (Mounjaro®) vs Semaglutide (WegovyTM)

Tirzepatide (Mounjaro®) and Semaglutide (WegovyTM) are alike in many ways. They’re both medications for the treatment of obesity and/or weight management. They both target the brain’s appetite control center, which is responsible for regulating appetite and metabolism. And, they’re both considered safe by the FDA (although for different reasons.)

What’s different about the two drugs is how they work and the benefits they offer as a result. Semaglutide (WegovTMy) works by increasing the body's production of glucagon-like peptide-1 (GLP-1) in order to increase feelings of satiety and decrease appetite, so that you eat less and lose weight in the process. 

Tirzepatide (Mounjaro®) on the other hand, works by increasing the body's production of glucagon-like peptide-1 (GLP-1), as well as glucose-dependent insulinotropic polypeptide (GIP). By imitating two hunger hormones instead of one, Tirzepatide (Mounjaro®) increases insulin production, decreases glucagon production, and reduces appetite—helping you lose weight and improve your markers of insulin resistance.

Who Are They For?

Tirzepatide (Mounjaro®) and Semaglutide (WegovyTM) are both designed for weight management, but they’re better for different individuals. For those looking to lose weight quickly, it may be best to opt for the former, as Tirzepatide has been shown to produce faster weight loss than Semaglutide. In fact, those who take Tirzepatide often lose an average of 8-15 pounds per month vs 4-6 pounds per month for Semaglutide.

That said, Semaglutide may be the better option for those who care more about sustained weight loss over a longer period of time, or who have been advised to do so for medical reasons. While its greatest benefits may take time to be achieved, those who stick with the drug can hope for long-term, sustainable results.

Why is Tirzepatide (Mounjaro®) So Popular?

Tirzepatide (Mounjaro®) has become increasingly popular due to its higher efficacy rate and decreased risk of side effects. 

One of the biggest advantages of Tirzepatide (Mounjaro®) over Semaglutide (WegovyTM) is the amount of weight loss seen when taking the shot. Studies have shown that individuals who use Tirzepatide (Mounjaro®) for a year lose an average of 22.5% of their body weight compared to a 15% weight loss observed in individuals who use Semaglutide (WegovyTM). As mentioned above, Tirzepatide (Mounjaro®) has also been shown to have faster weight loss effects than Semaglutide (Wegovy), contributing to its popularity as an effective weight loss shot.

Moreover, Tirzepatide (Mounjaro®) is typically taken for a shorter course than Semaglutide (WegovyTM), with a typical treatment period ranging between 2-4 months*, compared to the 12-month treatment period associated with Semaglutide (WegovyTM). This makes Tirzepatide (Mounjaro®) a more convenient option for those looking to lose weight quickly in a short period of time. 

*Many people who take Tirzepatide do a maintenance dose for several months after their initial weight loss period to prevent any sudden rebound weight gain. 


In conclusion, Tirzepatide (Mounjaro®) and Semaglutide (WegovyTM) are both effective medications for the treatment of obesity and/or weight management. But, Tirzepatide (Mounjaro®) has become much more popular due to its higher rate of weight loss, ease of compliance, and lower risk of side effects. If you’re looking for an effective weight-loss medication, Tirzepatide (Mounjaro®) may be the right choice for you.

Try Tirzepatide (Mounjaro®) in Austin Today!

Want to reach your ideal weight? Our (new!) Tirzepatide (Mounjaro®) for Weight Loss Program is the way to go! With this exclusive program, you’ll receive a free assessment with a weight loss coach in Austin, a 4-week prescription supply of Tirzepatide (Mounjaro®), and a FREE diet protocol for only $795 for the first two months. We’ll even throw in four FREE B12 energy shots to help you lose weight faster and improve your mood!

Schedule your assessment today to find out if Tirzepatide (Mounjaro®) is right for you!

Begin Your Weight Loss Journey!

If you’re ready to feel like yourself again, Blue Tree Health can help! We offer comprehensive weight loss programs that are custom-made for you and your goals. On top of that, we also offer body contouring treatments, vitamin shots, and food sensitivity tests. So whether it’s 10 pounds or up to 100 pounds, Blue Tree Health is here to help you lose the weight!